In a smaller, separate deal, in February 2011, BASF and Sigma-Aldrich signed a global distribution agreement for several of
BASF's pharmaceutical excipients. Under the deal, Sigma-Aldrich will repackage the products into small pack sizes to make
them available for academic-oriented R&D activities for use by universities and laboratories. The excipients portfolio offered
comprises various grades of binders (i.e., Kollidons), coatings (i.e., Kollicoats), and solubilizers (i.e., Cremophors, Lutrols,
On the new product front, BASF introduced Kollicoat Smartseal 30 D, a water-based dispersion for taste-masking and moisture-barrier
applications, in 2010. The product is highly impermeable to water vapor, which facilitates preserving the potency of sensitive
active ingredients, according to a Nov. 15, 2010, BASF press release. The polymer is stable in saliva and soluble in gastric
juice. These properties ensure effective protection from unpleasant taste in the patient's mouth and rapid release and onset
of active ingredient action in the stomach, according to the BASF press release. Kollicoat Smartseal 30 D complements BASF's
existing tablet coatings portfolio, which includes polymers and copolymers used to coat tablets, capsules, and pellets, and
to control the release of drugs from solid dosage forms.
The specialty- and fine-chemicals company Evonik reorganized, effective Sept. 1, 2011, and combined its businesses for custom
API manufacturing (i.e., exclusive synthesis), pharmaceutical amino acids (i.e., its Rexim product line), and pharmaceutical
polymers in a new healthcare business line. The pharmaceutical polymers business includes the company's Eudragit and Resomer
product lines. The Eudragit line consists of acrylic copolymers for oral solid dosage forms, and the Resomer line includes
bioresorbable poly(lactic-co-glycolic acid) copolymers, which are used in depot formulations. Evonik acquired the Resomer
business from Boehringer Ingelheim in March 2011.
Avantor Performance Chemicals.
Avantor Performance Chemicals is proceeding with an expansion in India, following a key acquisition in 2010. Avantor Performance
Chemicals was the new name given to the company after the acquisition of Mallinckrodt Baker from Avantor's former parent company,
Covidien, to the private equity group, New Mountain Capital. Avantor is a producer of products and materials for the pharmaceutical
industry, including excipients.
In May 2011, Avantor opened a new pharmaceutical formulation application laboratory in Sinnar Nashik, Maharashtra, India,
with its partner RanQ Remedies. The new laboratory will be used to characterize excipients, perform functional testing, develop
and characterize drug formulations, and support customer applications and product implementation. In terms of excipients,
RanQ has a position in microcrystalline cellulose and sodium starch glycolate and also has expertise in developing premixed
and other application-focused pharmaceutical excipients that result in a homogenous mix and coprocessed excipients.
In addition to the applications laboratory, Avantor completed construction of a pilot plant onsite at the RanQ facility. The
pilot plant will be used to develop and scale up additional performance excipients to extend Avantor's J.T. Baker PanExcea
product line. The PanExcea line includes performance excipients that combine fillers, binders, and disintegrants for increased
functionality for immediate-release formulations and orally disintegrating tablet applications.
Several other excipient companies are expanding. In 2011, DMV–Fonterra agreed to acquire the business and assets of Brahmar
Cellulose Private Ltd. an Indian-based producer of pharmaceutical microcrystalline cellulose and sodium carboxylmethylcellulose.
The acquisition, subject to customary closing conditions and regulatory approval, is scheduled to close in the fourth quarter
In April 2011, FMC completed an expansion of its microcrystalline cellulose plant in Cork, Ireland. Production from the final
phase of the expansion began in March 2011 and increased FMC's global capacity by 25% for pharmaceutical- and food-grade microcrystalline
cellulose. FMC operates another microcrystalline cellulose plant in Newark, Delaware.
In March 2011, Grace Davison Discovery Sciences, part of W.R. Grace & Co., opened a new technical service knowledge center
in Southern India for customers in the pharmaceutical and biotechnology industries. The new facility is located in the Genome
Valley near Hyderabad. The knowledge center supports Grace's customers in the areas of excipients, pharmaceutical intermediates,
laboratory separations, and bulk purification. The center also will provide product development and applications support and
include such services as customer training, validation, testing for various products, and product demonstrations. The new
center complements existing application laboratories in the United States, Europe, and China.
In October 2010, ABITEC and Mutchler Pharmaceutical Ingredients, announced a comarketing and distribution partnership for
ABITEC's Captex, Capmul, Acconon, Sterotex, BBS-C, and Hydro-Kote lipid-based pharmaceutical-grade excipients. The partnership
provides for expanded customer service, sales, technical formulation-development support, and supply capability.