The Development of a Floating Drug-Delivery System for Metronidazole - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

The Development of a Floating Drug-Delivery System for Metronidazole
The authors developed a metronidazole-based floating drug-delivery system to investigate the effect of rate-controlling polymers on release pattern and duration of buoyancy in matrix tablets.

Pharmaceutical Technology
pp. 41-44


1. A.A. Deshpande et al., Pharm. Res. 14 (6), 815–819 (1997).

2. F. Stops et al., Int. J. Pharm. 308 (1–2), 8–13 (2006).

3. F. Stops et al., Int. J. Pharm. 308 (1–2), 14–24 (2006).

4. S.C. Sweetman, "Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Metronidazole," in The Complete Drug Reference, C.F. Rediguieri et al., Eds. (Pharmaceutical Press, London, 36th ed., 2009), pp. 837–841.

5. J.S. Simms-Cendan, J. Infect. Dis. 3 (5), 153–156 (1996).

6. J.W. Tracy and L.T. Webster, Jr., "Drugs Used in the Chemotherapy of Protozoal Infections," in The Pharmacological Basis of Therapeutics, J.G. Hardman, L.E. Limbird, and A.G. Gilman, Eds. (McGraw-Hill, New York, 10th ed., 2001), pp. 1105–1109.

7. K.C. Lamp et al., Clin. Pharmacokinet. 36 (5), 353–373 (1999).

8. E.D. Ralph et al., Antimicrob. Agents Chemother. 6 (6), 691–696 (1974).

9. B.N. Singh and K.H. Kim, J. Control Release 63 (3), 235–259 (2000).

10. S. Burton et al., J. Pharm. Pharmacol. 47 (11), 901–906 (1995).

11. V. Alvisi et al., Drugs Exp. Clin. Res. 22 (1), 29–33 (1996).

12. M. Rahman et al., J. Pharmaceutics Cosmetol. 1 (2), 81–92 (2011).

13. M.D. Chavanpatil et al., Int. J. Pharm. 316 (1–2), 86–92 (2006).

14. T. Higuchi, J. Pharm. Sci. 52 (12), 1145–1149 (1963).

15. S. Asnaashari et al., Pharm. Dev. Technol. 16 (4), 1–8 (2010).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
View Results
Eric Langerr Outsourcing Outlook Eric LangerTargeting Different Off-Shore Destinations
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAsymmetric Synthesis Continues to Advance
Jill Wechsler Regulatory Watch Jill Wechsler Data Integrity Key to GMP Compliance
Sean Milmo European Regulatory WatchSean MilmoExtending the Scope of Pharmacovigilance Comes at a Price
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Source: Pharmaceutical Technology,
Click here