Antibody-Drug Conjugates: Looking Ahead to an Emerging Class of Biotherapeutic - Pharmaceutical Technology

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Antibody-Drug Conjugates: Looking Ahead to an Emerging Class of Biotherapeutic
Creating a successful antibody-drug conjugate requires careful selection of the drug, antibody, and linker.


Pharmaceutical Technology
Volume 36, Issue 1, pp. 42-47

Looking ahead

The future of ADCs in the biopharmaceutical market will ultimately depend on their clinical success. Companies and researchers are seeking to meet that challenge by optimizing the selection of all the components in the ADC—the antibody, linker, and cytotoxin—and successfully combining manufacturing techniques for both high- potency APIs and biologics. ADCs are sometimes described as armed antibodies, and their cytotoxic components as warheads. Whether ADCs will prove to be an effective weapon against cancer or other diseases has yet to be seen as more are tested in the clinic.

References

1. FDA, "Label for Adcetris, BLA 125338," FDA Approved Drug Products: Drugs@FDA, accessed Dec. 20, 2011.

2. V.S. Goldmacher and Y.V. Kovtun, Ther. Deliv. 2 (3), 397–416 (2011).

3. F. Dosio, P. Brusa and L. Cattel, Toxins 3, 848–883 (2011).

4. H.A. Burris, Expert Opin. Biol. Ther. 11 (6), 807–819 (2011).

5. A. Beck et al., Discov. Med. 10 (53), 329–359 (2010).

6. S.V. Govindan and DM Goldenberg, Scientific World Journal 10, 2070–2089 (2010).

7. Junutula et al., Nat. Biotechnol. 26 (8), 925-932 (2008).

8. Junutula et al., Clin. Canc. Res. 16, 4769–4778 (2010).

9. A. Ritter Pharm. Tech. 35 (6), 36–39 (2011).

10. Zawada et al., Biotech. Bioeng. 108 (7), 1570–1578 (2011).


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