Facilitating Efficient Equipment Cleaning - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Facilitating Efficient Equipment Cleaning
Equipment design and cleaning procedures both play a role in thorough sterilization and cleaning.


Pharmaceutical Technology
Volume 36, Issue 5, pp. 62-64

Testing TACT parameters


Figure 2: A tank cleaned with (a) two static spray balls and (b) one rotating jet head.
To test the influence of the TACT parameters, the author designed a tank-cleaning test incorporating two tank-cleaning devices that generated different amounts of action. A static spray ball typically generates a wall shear stress of 2–5 Pa (i.e., falling film stress, depending on liquid temperature). A rotating jet head typically generates a wall shear stress of 40–1000 Pa (i.e., jet impingement, depending on jet pattern mesh).


Table I: Parameters of two cleaning operations.
To clean the tank sufficiently, two static spray balls operated for 48 min at a flow rate of 20 m3/h and a system pressure of 2.5 bar. One rotating jet head, however, achieved better results when it operated for 14 min at a flow rate of 6 m3/h and a system pressure of 5.0 bar (see Figures 2 and 3 and Table I).


Figure 3: TACT circles for (a) two static spray balls and (b) one rotating jet head.
The test showed that the theory of the TACT circle works in practice. To clean a certain residue from a certain surface, the parameters in the TACT circle can be adjusted for cost optimization (see Figure 3). With increased action, it was possible to reduce the time, the amount of chemicals, and the heating energy and still achieve an equal or better result. High shear forces can remove residues from most surfaces by themselves without chemicals or high temperatures. This technique can reduce the risk of contamination from cleaning chemicals and dramatically reduce cleaning costs.


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
32%
Breakthrough designations
11%
Protecting the supply chain
37%
Expedited reviews of drug submissions
11%
More stakeholder involvement
11%
View Results
Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
Sandoz Wins Biosimilar Filing Race
NIH Translational Research Partnership Yields Promising Therapy
Clusters set to benefit from improved funding climate but IP rights are even more critical
Supplier Audit Program Marks Progress
FDA, Drug Companies Struggle with Compassionate Use Requests
Source: Pharmaceutical Technology,
Click here