Another key aspect of excipient selection in new solubilization technologies is the structure-property correlation in the
formulation. Current excipient selection is often empirical or semi-empirical. The interaction of excipients with drug in
the formulation is poorly understood and development of the in vitro/in vivo correlation still remains an obstacle to the
new solubilization technology based formulations. With more understanding of interactions of the drug with excipients in the
formulation and the drug/excipients with the gastrointestinal tract environment, it could be possible in the future to establish
structure-property correlation in the new techniques based formulations.
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