2,4,6-Tribromoanisole and 2,4,6-Trichloroanisole - Pharmaceutical Technology

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PharmTech Europe

2,4,6-Tribromoanisole and 2,4,6-Trichloroanisole
A review of taints and odors in the pharmaceutical and consumer healthcare industries.

Pharmaceutical Technology
Volume 36, Issue 9, pp. 56-62


1. PDA, "Technical Report No. 55: Detection and Mitigation of 2,4,6-Tribromoanisole and 2,4,6-Trichloroanisole Taints and Odors in the Pharmaceutical and Consumer Healthcare Industries," (April 2012), available at http://store.pda.org/ProductCatalog/Product.aspx?ID=1549.

2. Anon, "Organohalogen Taints in Foods," Australian Food and Grocery Council Supplement to Food Australia, 59 (3), (2007), http://www.afgc.org.au/cmsDocuments/Organohalogen.pdf

3. PDA, "Risk Mitigation of Tribromoanisole (TBA)/Trichloroanisole (TCA) Taints and Odors: A Pharmaceutical Industry Benchmarking Survey" (2011), available at http://store.pda.org/bookstore/ProductDetails.aspx?productabbreviation=45000.

4. FDA, "Questions and Answers on Current Good Manufacturing Practices, Good Guidance Practices, Level 2 Guidance–Buildings and Facilities" (FDA, Rockville, MD), http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm192869.htm.

5. T. Ramstad and J.S.Walker, Analyst 117 (8), 1361–1366 (1992).

6. R.J. Bleiler, F. Kuhrt, and D. Wright, Analytical Technology and Laboratory Testing, supp. to Pharm. Technol. 35 (11) s10-14 (2011).

7. F. Koshier et al., Food Chem. Toxicol. 49 (9), 2074–2080 (2011).

8. ICH, Q9 Quality Risk Management (2005).

9. ISO 13299:2003, Sensory Analysis-General Guidance for the Design of Test Rooms.


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