A Lifecycle Approach to Optimizing Cleaning Systems - Pharmaceutical Technology

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A Lifecycle Approach to Optimizing Cleaning Systems
Clean-in-place systems should be optimized during design and commissioning and after validation.


Pharmaceutical Technology
Volume 36, Issue 12

Conclusion


Table III: Time-reduction analysis.
An optimal cleaning system requires effort throughout the product lifecycle. Both the mechanical and automation designs require thoughtful consideration. Optimal cleaning parameters should be explored in the laboratory design space, before scale-up and during commissioning. Once the process moves to the qualification phase, data trending and analysis should be used to establish recipe parameters. Finally, after commissioning and qualification, cycle changes and improvements should be controlled through analysis of cost, time, and resource benefits. By taking this comprehensive and holistic view, the user can truly maximize the capability and efficiency of their cleaning program.

Andrew Wong and Cody Shrader are senior engineers at Hyde Engineering + Consulting, Boulder, CO,
.

Reference

1. The American Society of Mechanical Engineers, ASME BPE-2009, Bioprocessing Equipment (New York, NY, 2009).


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