An optimal cleaning system requires effort throughout the product lifecycle. Both the mechanical and automation designs require
thoughtful consideration. Optimal cleaning parameters should be explored in the laboratory design space, before scale-up and
during commissioning. Once the process moves to the qualification phase, data trending and analysis should be used to establish
recipe parameters. Finally, after commissioning and qualification, cycle changes and improvements should be controlled through
analysis of cost, time, and resource benefits. By taking this comprehensive and holistic view, the user can truly maximize
the capability and efficiency of their cleaning program.
Table III: Time-reduction analysis.
Andrew Wong and Cody Shrader are senior engineers at Hyde Engineering + Consulting, Boulder, CO, Andrew.Wong@Hyde-EC.com
1. The American Society of Mechanical Engineers, ASME BPE-2009, Bioprocessing Equipment (New York, NY, 2009).