Continuous Improvement in Tablet Coating and Dry Granulation - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Continuous Improvement in Tablet Coating and Dry Granulation
Recent advances in equipment design and operation in spraying, drying, and mixing can improve the tablet-coating process.


Pharmaceutical Technology
pp. s12-s16

Conclusion

This study proves the functionality of the new roller compactors. It was possible to precisely produce a representative placebo granule formulation with negligible material waste during process start-up. Furthermore, the study shows that a suitable sieve setup offers the possibility to achieve a desired granule size by altering screen size and sieve speed.

References

1. R. Mueller and P. Kleinebudde, Eur. J. Pharm. Biopharm. 64 (3), 388-92 (2006).

2. R. Mueller et al., Drug. Dev. Ind. Pharm. 36 (2), 234-243 (2010).

3. R. Mueller and P. Kleinebudde, AAPS PharmSciTech. 28 (1), E21-31 (2007).

4. R.W. Miller, Pharm. Technol. 18 (3), 154-162 (1994).

5. P. Kleinebudde, Eur. J. Pharm. Biopharm. 58 (2), 317-326 (2004).

6. Y. Teng, Z. Qiu, and H. Wen, Eur. J. Pharm. Biopharm. 73 (2), 219-229 (2009).

Martin Hack* is vice-president and general manager, and Dejan Djuric, PhD, is manager of scientific operations, both at L.B. Bohle, 700 Veterans Circle, Suite 100, Warminster, PA 18974, tel. 215.957.1240,

* To whom all correspondence should be addressed.


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here