Continuous Improvement in Tablet Coating and Dry Granulation - Pharmaceutical Technology

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PharmTech Europe

Continuous Improvement in Tablet Coating and Dry Granulation
Recent advances in equipment design and operation in spraying, drying, and mixing can improve the tablet-coating process.


Pharmaceutical Technology
pp. s12-s16

Conclusion

This study proves the functionality of the new roller compactors. It was possible to precisely produce a representative placebo granule formulation with negligible material waste during process start-up. Furthermore, the study shows that a suitable sieve setup offers the possibility to achieve a desired granule size by altering screen size and sieve speed.

References

1. R. Mueller and P. Kleinebudde, Eur. J. Pharm. Biopharm. 64 (3), 388-92 (2006).

2. R. Mueller et al., Drug. Dev. Ind. Pharm. 36 (2), 234-243 (2010).

3. R. Mueller and P. Kleinebudde, AAPS PharmSciTech. 28 (1), E21-31 (2007).

4. R.W. Miller, Pharm. Technol. 18 (3), 154-162 (1994).

5. P. Kleinebudde, Eur. J. Pharm. Biopharm. 58 (2), 317-326 (2004).

6. Y. Teng, Z. Qiu, and H. Wen, Eur. J. Pharm. Biopharm. 73 (2), 219-229 (2009).

Martin Hack* is vice-president and general manager, and Dejan Djuric, PhD, is manager of scientific operations, both at L.B. Bohle, 700 Veterans Circle, Suite 100, Warminster, PA 18974, tel. 215.957.1240,

* To whom all correspondence should be addressed.


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