Romaco’s family of liquid filling machines includes six models that handle vials and bottles ranging from 2–500 mL at speeds
of up to 200 containers per minute. Features include multiple dosing system and volumetric pump options, adjustable positive
container transport for fast changeover, multiple closure stations and cap feeding systems, and programmable setup and recall
of product recipes and production parameters. The systems integrate seamlessly with labelers and cartoners (Romaco Macofar
LF-200 Series liquid filling machines, MG America, subsidiary of MG2).
Groninger’s high-speed, aseptic vial-filling line handles 400 vials per minute. Compatibility with time-pressure, rotary piston,
and peristaltic pumps increases system flexibility and allows it to fill different products. A vial-handling system eliminates
damage and noise associated with glass-to-glass contact (see Figure 1). A three-fold camera checks for glass particles, residues,
or deposits inside the vial to prevent contamination of the product and also can inspect filling and closing steps (Kombi
Filling Rack on vial filling line, Groninger USA).
Figure 1: Groninger’s aseptic vial-filling line offers contact-free container handling. FIGURE 1 COURTESY OF GRONINGER USA
A high-speed line from Marchesini Group, capable of filling parenteral products at 400 vials per minute, consists of a rotary
washing machine, depyrogenation tunnel, and filling/stoppering machine. The eight-station rotary washer cleans ampules, vials,
and other round containers and features quick size-changeover. A modular design accommodates the addition of an ultrasonic
prewasher, silicone applicator, heat exchangers, filters, automatic valves, automatic drainers, pressure transmitters, and
unloaders to tunnel or tray. The continuous-motion depyrogenation tunnel relies on modular design as well as hot-air flow.
A pressurization system independently controls conditions in different sections of the tunnel. Proprietary cooling-zone sterilization
cuts cycle time in half. The continuous-motion, in-line filler/capper features an ultra-clean balcony design and is compatible
with restricted access barrier systems and isolators, as well as clean- and sterilize-in-place configurations. Other features
include contact-free vial handling, camera inspection, and checkweighing. Pump options include peristaltic, time-pressure,
and volumetric (WR24 washing machine, Depyr601 tunnel and Stery LC filling/stoppering machine, Marchesini Group).