Miniaturization of a Simulated Gastric Fluid Dispersion Experiment On a Microfluidics System - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Miniaturization of a Simulated Gastric Fluid Dispersion Experiment On a Microfluidics System
The miniaturization of preclinical safety assessment studies using a microfluidic chip system and optical microscopy can help reduce compound requirements, time, and costs in formulation development.


Pharmaceutical Technology
Volume 37, Issue 4, pp. 94-100

Acknowledgement

The authors gratefully acknowledge the New Technology Research License Committee of Merck & Co. for funding these experiments as well as Richard Gray, head of sales at Dolomite for helpful discussions.

References

1. P. Li and L. Zhoa, Int. J. Pharmaceutics 341 (1-2), 1-19 (2007).

2. J.B. Dressman and C. Reppas, Eur. J. of Pharm Sci. 11 (S2), S73-S80 (2000).

3. X. Casadevall i Solvas and A. deMello, Chem. Commun. 47 (7), 1936-1942 (2011).

4. Y. Wen and S.T. Yang, Expert Opin. Drug Discov. 3 (10), 1237-1253 (2008).

5. L. Kang et al., Drug Discovery Today 13 (1/2), 1-13 (2008).

6. S. Okushima et al., Langmuir 20 (23), 9905-9908 (2004).

7. V. Ravichandiran, K. Masilamani, and B. Senthilnathan, Der Pharmacia Sinica 2 (1), 19-30 (2011).

8. A. Jahn et al., Langmuir 23 (11), 6289-6293 (2007).

9. S.Y. Teh et al., Lab Chip. 8 (2), 198-220 (2008).

10. P.A. Tabeling, Lab Chip. 9 (17), 2428-2436 (2009).

11. A. Pathak et al., Drug Invention Today 2 (2), 123-129 (2010).

12. W-G. Dai et al., Int. J. Pharmaceutics 336 (1), 1-11 (2007).

13. P. Mansky et al., J. Pharm. Sciv. 96 (6), 1548-1563 (2007).

14. W-G. Dai et al., J. Pharm. Sci. 96 (11), 2957-2969 (2007).

15. S. Gopinathan, A. Nouraldeen, and A.G.E. Wilson, Future Med. Chem. 2 (9), 1391-1398 (2010).

16. C.R. Gardner, C.T. Walsh, and O. Almarsson, Nature Rev. Drug Disc. 3 (11), 926-934 (2004).

17. C.R. Gardner et al., Comp. Chem. Eng. 28 (6-7), 943-953 (2004).

18. H. Gu, M.H.G. Duits, and F. Mugele, Int. J. Mol. Sci. 12 (4), 2572-2597 (2001).

19 X. Casadevall i Solvas et al., Anal. Chem. 82 (9), 3950-3956 (2010).

Nicole L. Hill*, PhD, is a principal scientist in the Basic Pharmaceutical Sciences Group at Merck & Co., 2015 Galloping Hill Road, Kenilworth, NJ 07033, tel: 732.594.2009, nicole_hill@merck.com. Todd Nelson, PhD, is an executive director in the Process Chemistry Group, Tim Rhodes, PhD, is a senior principal scientist in the Analytical Sciences Group, and Allen Templeton, PhD, is an executive director in the Basic Pharmaceutical Science Group, all at Merck & Co. Elizabeth Kwong, PhD, is a consultant with Kwong Eureka Solutions, and formerly a senior scientific director with the Basic Pharmaceutical Sciences Group at Merck & Co. Brian Farrer, PhD, is a principal scientist at Liquidia Technologies, and formerly a principal scientist with the Basic Pharmaceutical Sciences Group at Merck & Co.

*To whom correspondence should be addressed.

Submitted: Oct. 2, 2012; Accepted Nov. 12, 2012.

All figures are courtesy of the authors


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
FDASIA was signed into law two years ago. Where has the most progress been made in implementation?
Reducing drug shortages
Breakthrough designations
Protecting the supply chain
Expedited reviews of drug submissions
More stakeholder involvement
Reducing drug shortages
70%
Breakthrough designations
4%
Protecting the supply chain
17%
Expedited reviews of drug submissions
2%
More stakeholder involvement
7%
View Results
Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
Faiz Kermaini Industry Insider Faiz KermainiNo Signs of a Slowdown in Mergers
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Ebola Outbreak Raises Ethical Issues
Better Comms Means a Fitter Future for Pharma, Part 2: Realizing the Benefits of Unified Communications
Better Comms Means a Fitter Future for Pharma, Part 1: Challenges and Changes
Sandoz Wins Biosimilar Filing Race
Source: Pharmaceutical Technology,
Click here