Miniaturization of a Simulated Gastric Fluid Dispersion Experiment On a Microfluidics System - Pharmaceutical Technology

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Miniaturization of a Simulated Gastric Fluid Dispersion Experiment On a Microfluidics System
The miniaturization of preclinical safety assessment studies using a microfluidic chip system and optical microscopy can help reduce compound requirements, time, and costs in formulation development.

Pharmaceutical Technology
Volume 37, Issue 4, pp. 94-100


The authors gratefully acknowledge the New Technology Research License Committee of Merck & Co. for funding these experiments as well as Richard Gray, head of sales at Dolomite for helpful discussions.


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Nicole L. Hill*, PhD, is a principal scientist in the Basic Pharmaceutical Sciences Group at Merck & Co., 2015 Galloping Hill Road, Kenilworth, NJ 07033, tel: 732.594.2009, Todd Nelson, PhD, is an executive director in the Process Chemistry Group, Tim Rhodes, PhD, is a senior principal scientist in the Analytical Sciences Group, and Allen Templeton, PhD, is an executive director in the Basic Pharmaceutical Science Group, all at Merck & Co. Elizabeth Kwong, PhD, is a consultant with Kwong Eureka Solutions, and formerly a senior scientific director with the Basic Pharmaceutical Sciences Group at Merck & Co. Brian Farrer, PhD, is a principal scientist at Liquidia Technologies, and formerly a principal scientist with the Basic Pharmaceutical Sciences Group at Merck & Co.

*To whom correspondence should be addressed.

Submitted: Oct. 2, 2012; Accepted Nov. 12, 2012.

All figures are courtesy of the authors


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