Using a Gravimetric Feeder to Dose Pharmaceutical Bulk Solids - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Using a Gravimetric Feeder to Dose Pharmaceutical Bulk Solids
Loss-in-weight feeders provide high accuracy for batch or continuous processes.

Pharmaceutical Technology
Volume 37, Issue 5, pp. 50-52

Measuring feeder accuracy

PharmTech: How is the accuracy of a gravimetric feeder determined?

Nowak: Weigh-feeder accuracy, regardless of the feeder type or design, is measured by weighing a series of timed catch-samples of material discharged from the feeder. The term 'weigh-feeder accuracy' refers to the combined effect of two distinct, but related, performance factors: linearity and repeatability.


Figure 2: Linearity measures the feeder’s ability to deliver a desired flow rate throughout the feeder’s range of operation.
Linearity, as the word implies, is a measure of the feeder's ability to deliver, on the average, the desired flow rate throughout the feeder's full range of operation (see Figure 2). A linearity measurement, therefore, reveals the difference between the actual and desired average sample weight at various flow settings. Repeatability, on the other hand, is a measure of the degree to which the feeder discharges a constant flow of material over a specified time period at a given flow-rate setting. Usually made at the intended nominal operating flow rate, a repeatability measurement indicates the level of scatter or dispersion (around the average sample weight) of the group of weighed catch samples.

A feeder's linearity measurement quantifies how well or poorly it delivers the desired average rate at each of various points throughout the feeder's complete operating range. Perfect linearity is represented by a straight-line relationship between the setpoint and the actual average feed rate throughout the feeder's specified turndown range from its design, full-scale operating range.

In addition, feeders should be designed to maintain accuracy during the refill phase, in which material is replenished in the feed hopper and the feeder is momentarily not being controlled by loss in weight. In the past, feeders were operated by a constant metering speed during refill, but because the bulk density of the material can change during refill, this often led to overfeeding. A more accurate method (Smart Refill Technology, K-Tron) stores trending data of the weight-to-speed ratio obtained while the hopper is emptying and uses this data to gradually change metering speed during refill. The speed correction allows the mass flow to remain constant during refill. Material characteristics (e.g., bulk density, particle size and shape, angle of repose, and gas permeability) and the refill hopper size also affect the refill process and its accuracy.

Using gravimetric feeders in continuous manufacturing

PharmTech: Continuous manufacturing is predicted to grow in use for solid-dosage manufacturing. What technology is needed to feed continuously?

Nowak: Gravimetric feeders are typically the technology of choice for continuous pharmaceutical processing, such as hot-melt extrusion or continuous direct compression, because the loss-in-weight controller is a real-time device that provides the accuracy needed for continuous process control. In a continuous process, the feeder sets the precise throughput for the downstream equipment, and feeding performance largely affects the performance of subsequent unit operations.

Due to the shorter residence times in continuous pharmaceutical processes, automatic sampling of feeder performance is often performed at smaller time intervals, from 15 seconds down to 5-second and even 1-second sampling. For this reason, it is imperative that the control system of the feeder chosen for continuous operations has fast response times. Although use of gravimetric feeders for continuous processing in the pharmaceutical industry is fairly new, these feeders have been an integral part of continuous processing in the food and plastics industries for decades.

Gravimetric feeders in tablet-press lubrication

PharmTech: How are gravimetric feeders used in tablet-press lubrication?

Nowak: Recently, gravimetric feeders have been used for direct, external lubrication of tablet presses, in which magnesium-stearate lubricant is blown into the press, which can reduce stearate use by as much as 97%. This significant reduction in the amount of lubricant added in the blending stage can drastically improve the blend properties, making it more free flowing as well as reducing the possibility of the formulation sticking to the tablet-press tooling. This concept was illustrated in a poster presented at an AAPS (American Association of Pharmaceutical Scientists) meeting (1). The use of a loss-in-weight feeder to control the rate of lubricant to the press allows processors to precisely measure how much is going in; by measuring how much stearate remains after processing, the amount of stearate in the formulation can be quantified (1). Typical feed rates of magnesium stearate for this application are 0.2–2 kg/h, and microfeeders allow rates as low as 50 g/h.

Reference

1. J. Nelson, S. Bell, M. Roy, J. Chu, and K. Waterman "Consistency of Magnesium Stearate Content Using External Lubrication in Tablet Compression," poster presentation at AAPS Annual Meeting & Exposition (Atlanta, Georgia, 2008).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
26%
Attracting a skilled workforce
29%
Obtaining/maintaining adequate financing
14%
Regulatory compliance
31%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Pharmaceutical Technology,
Click here