Product Spotlight: Analytical Instrumentation - Pharmaceutical Technology

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Product Spotlight: Analytical Instrumentation
Editor's Pick's of Pharmaceutical Science & Technology Innovations: The latest in analytical instrumentation

Pharmaceutical Technology
Volume 37, Issue 8, pp. 13

Viscometer reveals polymer structure information
Malvern Viscotek viscometers can be used with gel permeation/size exclusion chromatography (GPC/SEC) to reveal polymer structure information by measuring viscosity parameters. This information enables researchers to modify polymer chain length and branching to meet precise goals. When used with a refractive index (concentration) detector, a viscometer gives information on molecular weight and density, which permits the determination of accurate molecular weight distributions without a relevant standard. On the other hand, if molecular weight is directly measured via a light-scattering technique, a viscometer enables the quantification of structural characteristics such a chain branching. The Viscotek viscometer can be supplied as part of an integrated triple detector Viscotek GPC/SEC system or as an addition to any existing separation system.


Gas-chromatography and mass spectrometry system analyzes complex mixtures
Jeol's AccuTOF GCV 4G high-resolution, time-of-flight mass-spectrometer system is offered with Zoex's comprehensive, two-dimensional gas-chromatography technology for analysis of complex mixtures. The system can be used in drug-metabolism studies to separate complex biological mixtures and identify known and uknown metabolites. The AccuTOF GCV 4G's unique capability to easily switch between electron ionization (EI) and field ionization (FI) modes combines the power of database searching in EI mode with unambiguous molecular weight information in FI mode. Unlike chemical ionization (CI), FI does not require a reagent gas, and FI mass spectra are very simple, consisting of molecular ions with little or no fragmentation. Accurate mass measurements can be carried out in either EI or FI mode or with the optional CI ion source.



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