Articles by Johannes G. Khinast - Pharmaceutical Technology

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Articles by Johannes G. Khinast

Comparing Manufacturing Process Options

A techno-economic optimization procedure supports pharmaceutical process development by providing a systematic approach to investigating and comparatively evaluating various manufacturing approaches for both traditional and innovative manufacturing technologies and to both existing and new products.
Aug 2, 2014

A techno-economic profiling method supports pharmaceutical process development by helping identify the best manufacturing approach.

Peer Reviewed: Numerical Simulation of Tablet Coating

The authors investigate the tablet-coating process using a combination of different simulation techniques.
Sep 2, 2012

The authors investigate the tablet-coating process using a combination of different simulation techniques.

Printable Medicines: A Microdosing Device For Producing Personalized Medicines

The authors describe a new method for the production of personalised medicines involving the direct printing of drug solutions or suspensions containing APIs and excipients onto edible paper carrier materials utilising ultra-precise microdrop printing technology. The approach allows ultra-precise dosing of the API according to the specific requirements of each individual patient and is suited for highly active low-dose drugs.
Jan 7, 2011

The authors describe a new method for the production of personalised medicines utilising ultra-precise microdrop printing technology.

Effect of Droplet-Wake Phenomena on Mixing-Sensitive Pharmaceutical Reactions

Nov 2, 2006

Understanding the impact of reactive mass transfer and local flow in multiphase systems is crucial for maximizing reaction selectivity and minimizing the formation of byproducts. The authors study the influence of mixing on fast liquid–liquid reactions. The iodination of L-tyrosine was used to demonstrate the relationship of droplet size and shape on reaction selectivity and to verify computational predictions. By understanding that droplet dynamics affect the yield and selectivity of fast reactions, the formation of byproducts can be minimized by optimizing operating parameters.

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