The authors evaluate the effect of various mill types on particle-size distribution, flowability, tabletability, and compactibility.
Nov 2, 2008
By:
Thomas A. Vendola, Bruno C. Hancock
The authors evaluate the effect of various mill types on particle-size distribution, flowability, tabletability, and compactibility.
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Dec 2, 2006
By:
David B. Hedden, Dean Brone, Scott Clement, Mike McCall, Angela Olsofsky, Phenil J. Patel, James Prescott, Bruno C. Hancock
This article describes the design and development of a material-sparing fluidization segregation tester for use with pharmaceutical powders. This tester offers several improvements over the current ASTM standardized test practice. Less than 20 mL of material is required to characterize the fluidization segregation potential of a sample. Features of the tester include powder containment for potent compounds, in-process monitoring of the fluidization conditions, and sample retrieval without the need for subsampling or riffling for typical analyses.
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Apr 2, 2005
By:
Bruno C. Hancock
X-ray microtomography has great potential for improving the understanding of the structural features of solid dosage forms and the changes in those features during manufacturing, handling, and storage.This article describes the basic principles of the technique and provides examples of its potential applications.
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Apr 1, 2005
By:
Bruno C. Hancock, Matthew P. Mullarney
X-ray microtomography has great potential for improving the understanding of the structural features of solid dosage forms and the changes in those features during manufacturing, handling, and storage. This article describes the basic principles of the technique and provides examples of its potential applications.
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Apr 2, 2003
By:
Bruno C. Hancock
The authors provide a combined source of density data and show that denity can be used as an equipment-independent sclaing parameter in the manufacture of common pharmaceutical solids.
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