Articles by Paul Lopolito - Pharmaceutical Technology

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Articles by Paul Lopolito

Rouge & Biofilm: Compounding Cleaning Challenges

Jul 30, 2014

Rouge and biofilm are commonly found in pharmaceutical manufacturing vessels and process piping. The presence of rouge on stainless steel surfaces may promote the development of biofilm and make it more difficult to remove. A robust cleaning and derouging procedure followed by process disinfection can be effective in controlling microbial contamination associated with biofilm.

Addressing Rouge in Biopharmaceutical Manufacturing Systems

Sep 15, 2010

The author describes the types and sources of rouge and explains ways to prevent and mitigate this problem.


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