Articles by Brian Schram - Pharmaceutical Technology

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Articles by Brian Schram

A Novel Process for Developing Fully Human Monoclonal Antibodies

The authors describe a process for generating high affinity, fully human antibodies in culture. Specially selected splenocytes are incubated with cytokines and low levels of antigen, yielding affinity-matured, class-switched B cells. The fully human, specific antibodies produced by these cells can then be cloned and expressed for further characterization.
Nov 1, 2012

The authors describe a process for generating high affinity, fully human antibodies in culture.

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