Articles by Cynthia Challener, PhD - Pharmaceutical Technology

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Articles by Cynthia Challener, PhD

New Solid Dose Technologies Highlighted at 2013 AAPS Annual Meeting & Expo

Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting
Dec 4, 2013

Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting.

Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates

Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death.
Nov 13, 2013

Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death.

Careful Process Mapping Can Significantly Reduce Product Losses in Fill-Finish Operations

Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line.
Nov 13, 2013

Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line.

On-Demand Drug Release Possible with Thermo-Responsive Polymers

On-demand drug release has the potential to reduce the side effects associated with the over-dosage of drugs, particularly for highly potent anti-cancer therapies.
Oct 9, 2013

On-demand drug release has the potential to reduce the side effects associated with the over-dosage of drugs, particularly for highly potent anti-cancer therapies.

Plasmon Resonance Microscopy Enables Analysis of Molecular-Scale Phenomena in Living Systems

Plasmonic imaging overcomes the limitations of traditional microscopy and can be used for the analysis of single cells, cell organelles, viruses, and even single protein-protein interactions.
Oct 9, 2013

Plasmonic imaging overcomes the limitations of traditional microscopy and can be used for the analysis of single cells, cell organelles, viruses, and even single protein-protein interactions.

Leveraging Single-Use Learnings in Fill-Finish Operations

After realizing benefits from the adoption of a single-use filling line for one specific product, Patheon took the leap and installed a single-use filling line in a new facility.
Oct 9, 2013

After realizing benefits from the adoption of a single-use filling line for one specific product, Patheon took the leap and installed a single-use filling line in a new facility.

Sterile, Automated Sampling Enabling PAT for Biopharmaceutical Manufacturing

Pfizer, Eli Lilly, and several other pharmaceutical companies are participating in the development of automated sampling technology and associated software that improve process control and reduce development times in biopharmaceutical manufacturing.
Oct 9, 2013

Pfizer, Eli Lilly, and several other pharmaceutical companies are participating in the development of automated sampling technology and associated software that improve process control and reduce development times in biopharmaceutical manufacturing.

Exploring Single-Use Systems for Fill-Finish Operations

The need to develop a final formulation process for a parenteral product sensitive to stainless-steel gave Patheon the opportunity to evaluate the potential of single-use technology in fill-finish operations.
Oct 9, 2013

The need to develop a final formulation process for a parenteral product sensitive to stainless-steel gave Patheon the opportunity to evaluate the potential of single-use technology in fill-finish operations.

GlaxoSmithKline Adopts Continuous Manufacturing for Preparation of Key Intermediate

Use of a continuous-flow reaction made it possible to scale up a highly exothermic reaction for the production of a key Suzuki−Miyaura coupling reagent.
Oct 9, 2013

Use of a continuous-flow reaction made it possible to scale up a highly exothermic reaction for the production of a key Suzuki−Miyaura coupling reagent.

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