Articles by Cynthia Challener, PhD - Pharmaceutical Technology

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Articles by Cynthia Challener, PhD

Boehringer Ingelheim Pharmaceuticals Uses Two-Dimensional Ultrahigh-Pressure Liquid Chromatography in Process Development

2D-UHPLC enabled the simultaneous analysis of reaction conversion and enantiomeric excess in asymmetric hydrogenations
Sep 11, 2013

2D-UHPLC enabled the simultaneous analysis of reaction conversion and enantiomeric excess in asymmetric hydrogenations

Mechanical Control with Foam Granulation Well-Suited for Pharmaceutical Manufacturing

Foam granulation is much easier to control under mechanical dispersion conditions, which is where most industrial processes operate.
Sep 11, 2013

Foam granulation is much easier to control under mechanical dispersion conditions, which is where most industrial processes operate.

Novartis Making Moves to Increase Biologics Manufacturing Capability

Novartis half-billion dollar investment in a new biologics production plant in Singapore represents a strategic commitment to its growing biologics portfolio.
Sep 11, 2013

Novartis? half-billion dollar investment in a new biologics production plant in Singapore represents a strategic commitment to its growing biologics portfolio.

Examining the Role of Cocrystals in Drug Development and Manufacturing

A recent FDA guidance places greater attention on cocrystals as a tool in solid-dosage formulation.
Sep 1, 2013

A recent FDA guidance places greater attention on cocrystals as a tool in solid-dosage formulation.

Advancing API Synthesis

Commercial-scale amide formation and an improved process route for a tetracycline derivative are some recent developments in API synthesis.
Sep 1, 2013

Commercial-scale amide formation and an improved process route for a tetracycline derivative are some recent developments in API synthesis.

UCLA Researchers Develop Nanocapsule for Targeted Delivery of Large-Molecule APIs

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects.
Aug 28, 2013

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects.

Catalent Moves Forward with New Single-Use Biopharmaceutical Manufacturing Facility

Extensive adoption of single-use technologies and unidirectional flow reduces cross-contamination risk in the companys new biomanufacturing facility.
Aug 28, 2013

Extensive adoption of single-use technologies and unidirectional flow reduces cross-contamination risk in the company?s new biomanufacturing facility.

Takeda Researchers Achieve Kilogram-scale GMP Production of a TORC1/2 Inhibitor

Installation of a quaternary chiral center with high enantioselectivity using memory of chirality enabled the six-step synthesis of the desired active compound.
Aug 28, 2013

Installation of a quaternary chiral center with high enantioselectivity using memory of chirality enabled the six-step synthesis of the desired active compound.

Making Cell-Imaging Systems More Accessible

Conventional cell-imaging systems that provide high quality data can be very expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.
Aug 28, 2013

Conventional cell-imaging systems that provide high quality data can be very expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.

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