Articles by Cynthia Challener, PhD - Pharmaceutical Technology

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Articles by Cynthia Challener, PhD

Evaporative Light Scattering Seeing Increased Use as Detector for Nonchromophoric Compounds

Difficult samples, including carbohydrates, triglycerides, lipids, phospolipids, underivatized fatty and amino acids, and modified peptides can be detected with high sensitivity and accuracy.
Dec 11, 2013

Difficult samples, including carbohydrates, triglycerides, lipids, phospolipids, underivatized fatty and amino acids, and modified peptides can be detected with high sensitivity and accuracy.

Novel Host Cell Line Targets Potential Sources of Immunogenicity in Chinese Hamster Ovary Cells

A novel host cell line trait stacked with knockouts of the CMAH and GGTA1 gene sequences is designed to produce safer therapeutic proteins.
Dec 11, 2013

A novel host cell line trait stacked with knockouts of the CMAH and GGTA1 gene sequences is designed to produce safer therapeutic proteins.

Novartis' US Influenza Cell-Culture Facility Recognized

For its use of innovative technology for the production of seasonal and pandemic influenza vaccines, the Novartis Holly Springs, North Carolina facility was the Overall Winner of the 2013 Facility of the Year Award issued by the International Society for Pharmaceutical Engineering (ISPE).
Dec 4, 2013

For its use of innovative technology for the production of seasonal and pandemic influenza vaccines, the Novartis Holly Springs, North Carolina facility was the Overall Winner of the 2013 Facility of the Year Award issued by the International Society for Pharmaceutical Engineering (ISPE).

New Solid Dose Technologies Highlighted at 2013 AAPS Annual Meeting & Expo

Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting
Dec 4, 2013

Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting.

Site-Specific Conjugation of Cytotoxic Cytolysins Could Lead to Highly Effective Antibody-Drug Conjugates

Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death.
Nov 13, 2013

Recent collaboration offers more heterogeneous, stable antibody drug conjugates of synthetic tubulin-binding agents shown to rapidly trigger cancer cell death.

Careful Process Mapping Can Significantly Reduce Product Losses in Fill-Finish Operations

Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line.
Nov 13, 2013

Changes in the working procedures and disposable fluid flow paths resulted in a measurable decrease in product waste in a low-volume, high-value fill-finish line.

On-Demand Drug Release Possible with Thermo-Responsive Polymers

On-demand drug release has the potential to reduce the side effects associated with the over-dosage of drugs, particularly for highly potent anti-cancer therapies.
Oct 9, 2013

On-demand drug release has the potential to reduce the side effects associated with the over-dosage of drugs, particularly for highly potent anti-cancer therapies.

Plasmon Resonance Microscopy Enables Analysis of Molecular-Scale Phenomena in Living Systems

Plasmonic imaging overcomes the limitations of traditional microscopy and can be used for the analysis of single cells, cell organelles, viruses, and even single protein-protein interactions.
Oct 9, 2013

Plasmonic imaging overcomes the limitations of traditional microscopy and can be used for the analysis of single cells, cell organelles, viruses, and even single protein-protein interactions.

Leveraging Single-Use Learnings in Fill-Finish Operations

After realizing benefits from the adoption of a single-use filling line for one specific product, Patheon took the leap and installed a single-use filling line in a new facility.
Oct 9, 2013

After realizing benefits from the adoption of a single-use filling line for one specific product, Patheon took the leap and installed a single-use filling line in a new facility.

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