Articles by Cynthia Challener, PhD - Pharmaceutical Technology

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Articles by Cynthia Challener, PhD

UCLA Researchers Develop Nanocapsule for Targeted Delivery of Large-Molecule APIs

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects.
Aug 28, 2013

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects.

Catalent Moves Forward with New Single-Use Biopharmaceutical Manufacturing Facility

Extensive adoption of single-use technologies and unidirectional flow reduces cross-contamination risk in the companys new biomanufacturing facility.
Aug 28, 2013

Extensive adoption of single-use technologies and unidirectional flow reduces cross-contamination risk in the company?s new biomanufacturing facility.

Takeda Researchers Achieve Kilogram-scale GMP Production of a TORC1/2 Inhibitor

Installation of a quaternary chiral center with high enantioselectivity using memory of chirality enabled the six-step synthesis of the desired active compound.
Aug 28, 2013

Installation of a quaternary chiral center with high enantioselectivity using memory of chirality enabled the six-step synthesis of the desired active compound.

Making Cell-Imaging Systems More Accessible

Conventional cell-imaging systems that provide high quality data can be very expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.
Aug 28, 2013

Conventional cell-imaging systems that provide high quality data can be very expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.

Porous Silica Gel Glidants Aid Direct Tablet Compression

Direct tablet compression is simpler than wet or dry granulation, but obtaining the right flow properties to ensure good compaction and uniform drug distribution can be a challenge. Porous silica gel, when used as a glidant, can address these issues.
Aug 28, 2013

Direct tablet compression is simpler than wet or dry granulation, but obtaining the right flow properties to ensure good compaction and uniform drug distribution can be a challenge. Porous silica gel, when used as a glidant, can address these issues.

Making Cell Imaging Systems More Accessible

Conventional cell-imaging systems that provide high quality data can be expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.
Aug 28, 2013

Conventional cell-imaging systems that provide high quality data can be expensive and complex to use. New systems from Biotek Instruments are designed to overcome these issues.

Merck/PITT Collaboration Demonstrates Rapid Method for Evaluation of Residual Palladium

A simple, rapid analytical method for the determination of palladium in pharmaceutical production samples will speed up development and optimization of reactions involving palladium catalysts.
Aug 14, 2013

A simple, rapid analytical method for the determination of palladium in pharmaceutical production samples will speed up development and optimization of reactions involving palladium catalysts.

Parallel Screening of Solid-State Characteristics Aids Formulation of Poorly Soluble Drugs

Rapid screening of critical API properties can quickly identify the best approach for increasing bioavailability.
Aug 14, 2013

Rapid screening of critical API properties can quickly identify the best approach for increasing bioavailability.

Tetraphase Pharmaceuticals Achieves Process-Scale Synthesis of New Tetracycline Derivative

Synthesis of tetracycline derivatives with novel substituents has been challenging. Using an approach based on a Michael-Dieckmann reaction, new compounds with enhanced antibiotic properties are now being prepared on a large scale.
Aug 14, 2013

Synthesis of tetracycline derivatives with novel substituents has been challenging. Using an approach based on a Michael-Dieckmann reaction, new compounds with enhanced antibiotic properties are now being prepared on a large scale.

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Eric Langerr Outsourcing Outlook Eric LangerRelationship-building at Top of Mind for Clients
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerRisk Reduction Top Driver for Biopharmaceutical Raw Material Development
Jill Wechsler Regulatory Watch Jill Wechsler Changes and Challenges for Generic Drugs
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