Articles by Dean Brone - Pharmaceutical Technology

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Articles by Dean Brone

Dean Brone

Dean L. Brone was a senior principal scientist at Pfizer Inc. (Ann Arbor, MI) and is currently the associate director of technical services with Sepracor (Marlborough MA).

Development of an Improved Fluidization Segregation Tester for Use with Pharmaceutical Powders
December 2, 2006

This article describes the design and development of a material-sparing fluidization segregation tester for use with pharmaceutical powders. This tester offers several improvements over the current ASTM standardized test practice. Less than 20 mL of material is required to characterize the fluidization segregation potential of a sample. Features of the tester include powder containment for potent compounds, in-process monitoring of the fluidization conditions, and sample retrieval without the need for subsampling or riffling for typical analyses.

Characterization of the Performance of Bin Blenders Part 1 of 3: Methodology
May 2, 2004

In this series of articles, bin blender performance is comprehensively reviewed using both free-flowing and cohesive mixtures. In part 1, an introduction to tools and techniques is presented, followed by an examination of parameter effects, mixing mechanisms, and the effects of cohesion on mixing.


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