Jacques Thilly

The authors present an aseptic-filling process for freeze-dried liquids using the closed-vial technology.

Manufacturers use various techniques to transfer sterile liquid. Some methods, however, cannot accommodate disposable equipment, and others cannot transfer through barriers. This article describes a new approach for aseptic fluid transfer that was developed to provide a high-quality aseptic connection and simplify passage through a wall. The authors discuss the product-qualification results for the approach, which show that the technology and its various components meet pharmacopeial product-qualification requirements.

A ready-to-fill closed vial can improve aseptic filling quality and reduce process complexity.