Articles by Jodi Raffensberger - Pharmaceutical Technology

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Articles by Jodi Raffensberger

Jodi Raffensberger

Jodi Raffensberger is a process engineer at Merck and Company.

Effect of Droplet-Wake Phenomena on Mixing-Sensitive Pharmaceutical Reactions
November 2, 2006

Understanding the impact of reactive mass transfer and local flow in multiphase systems is crucial for maximizing reaction selectivity and minimizing the formation of byproducts. The authors study the influence of mixing on fast liquid–liquid reactions. The iodination of L-tyrosine was used to demonstrate the relationship of droplet size and shape on reaction selectivity and to verify computational predictions. By understanding that droplet dynamics affect the yield and selectivity of fast reactions, the formation of byproducts can be minimized by optimizing operating parameters.


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