Articles by John M. Hayes - Pharmaceutical Technology

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Articles by John M. Hayes

John M. Hayes


John M. Hayes, PhD, is a scientist emeritus with Woods Hole Oceanographic Institution (Woods Hole, MA).

Process Patent Protection: Characterizing Synthetic Pathways by Stable-Isotopic Measurements
March 2, 2007

The authors describe the methods by which precise analyses of stable-isotopic abundances can be used in security and forensic applications for pharmaceutical materials. These methods include product and process authentication of raw materials, pharmaceutical intermediates, drug substances, formulated drug products, and synthetic pathways. Collectively, these methods can be used to investigate and mitigate patent infringement. In the future, more complete examples will be presented containing full isotopic results and the application of the methods described in this article.

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