Shimadzu

In the recent revision of USP <621>, the modification of parameters is allowed only when the chromatogram improvement is still within the stated system suitability factors. This note shows an example of Ibuprofen analysis from the USP-NF with a conventional column and a core-shell column.

In the recent revision of USP <621>, the modification of parameters is allowed only when the chromatogram improvement is still within the stated system suitability factors. This note shows an example of Ibuprofen analysis from the USP-NF with a conventional column and a core-shell column.

Within the pharmaceutical industry, TOC analyzers serve vital roles in the manufacturing process, from inspections of the water used in drug manufacture (ultrapure water) to evaluation of cleaning effectiveness (cleaning validation). This paper examines their use and presents some application data.

When analyzing viscous solutions by FTIR spectroscopy, the ATR method is particularly effective because the close contact between the sample and prism is easily achieved. This application illustrates an example with the analysis of dimethicone, with good repeatability clearly obtained.

When analyzing viscous solutions by FTIR spectroscopy, the ATR method is particularly effective because the close contact between the sample and prism is easily achieved. This application illustrates an example with the analysis of dimethicone, with good repeatability clearly obtained.

The United States Pharmacopoeia has established guidelines for determining system suitability and established the acceptance of Water For Injection (WFI) purposes and Purified Water (PW) (USP Method <643>). This papers examines the use of Shimadzu’s TOC for meeting these requirements.