Articles by Erin E. Chambers - Pharmaceutical Technology

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Articles by Erin E. Chambers

Erin E. Chambers
Simultaneous Quantitation of Multiple Amyloid Beta Peptides in Cerebrospinal Fluid Using SPE with UPLC/MS/MS
September 25, 2012
By: Erin E. Chambers , Waters

In this work, a fast and flexible platform that combines state-of-the-art sample extraction products with UPLC/tandem quadrupole mass specrometry for the quantification of multiple amyloid beta (aß) peptides from human or monkey CSF for use in a biomarker or preclinical discovery setting. The featured mass spectrometry platform is the Waters Xevo TQ-S mass spectrometry system, which facilitated both a 4X reduction in required sample size and a 4-5X increase in assay sensitivity compared to other LC/MS/MS systems.

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