David Worthen

High Viscosity Grade of Hydroxypropyl Cellulose (HPC) is thought as an effective controlled release (CR) material since it is a hydrophilic polymer. In this study, we investigated effects of viscosity, particle size, preparation method, and difference of controlled release polymer on drug release using Theophylline as model drug. The results showed viscosity, particle size, and preparation method affected the drug release, and optimization of particle size was more critical for DC method.

Processing techniques for low viscosity hydroxypropylcellulose polymers. Low viscosity HPC-SL and SSL can be employed to produce chemically stable SDs of poorly- as well as highly water-soluble drugs using various pharmaceutical processes in order to control API dissolution.