Pharmaceutical Technology, Apr 1, 2008 - Pharmaceutical Technology

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Pharmaceutical Technology, Apr 1, 2008
Drug Delivery
Polypeptide Multilayer Nanofilms in Drug Delivery
By Donald T. Haynie
Investigators are exploiting the tremendous structural diversity of polypeptides and their biophysical properties to develop novel drug carriers. Peptide-based materials hold out much promise for tailor-made targeting, penetration, and release of contents in a host of biological microenvironments.
Advances in Radio-Frequency Transdermal Drug Delivery
By Galit Levin
A microelectronic system based on radio-frequency (RF) cell ablation addresses limitations of other transdermal drug-delivery methods. This system expands the transdermal spectrum to include the delivery of water-soluble molecules, peptides, proteins, and other macromolecules.
Dissolvable Films: Dissolvable Films for Flexible Product Format in Drug Delivery
By Beth Vondrak , Scott Barnhart
For pediatric and geriatric patients, fast-dissolving drug-delivery systems provide an easier way to take medications and vitamins. Oral thin films have evolved to provide systemic delivery of active pharmaceutical ingredients for over-the-counter and soon, prescription drugs. The authors review the practical benefits of dissolvable films, their manufacture, and their market potential.
Suitability-for-Use Considerations for Prefilled Syringes
By Dennis Jenke
The nature of their application and their mode of use mean that prefilled syringes meet the regulatory definitions of immediate packaging or container–closure systems.
Challenges in the Secondary Manufacture of Encapsulated High-Potency Drugs
By Joe Carey , Andrew Dixon
Liquid and semisolid encapsulation using two-piece hard capsules is an ideal drug delivery approach for highly potent compounds and poorly water-soluble drugs. The authors detail the factors to reduce risk when designing and operating a facility for secondary manufacturing of highly potent drugs.

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