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Industrial Applications of Whole-Cell Biocatalysis
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Ulrich Becker
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Kai Doderer
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Steffen Osswald
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Stefan Verseck
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Wolfgang Wienand
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Recombinant microbial whole-cell biocatalysis is a valuable approach for producing enantiomerically pure intermediates. The authors examine several groups of enzymes using this approach: dehydrogenases, hydantoinases, and acylases.
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High-Potency APIs: Containment and Handling Issues
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David Bormett
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The author explains the planning, equipment, and facility design requried for manufacturing HPAPIs and specialized requirements for handling these compounds.
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Highly Efficient Olefin-Metathesis Catalysts
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Xiaochong Bei
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Daryl P. Allen
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Richard L. Pederson, PhD
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The authors describe the Piers' catalysts and detail latest progress in olefin-metathesis catalyst technology.
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Manufacturing Considerations for Sourcing GMP Fermentation Services
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Sheryl Henderson
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Steven McWethy
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Keith Dixon
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The authors describe the critical aspects of an ideal fermentation services provider.
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Power Ultrasound and the Production of Mesoscopic Particles and Aqueous Dispersions
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Graham Ruecroft
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Dipesh Parikh
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The authors discuss advanced sonocrystallization particle-engineering techniques for manufacturing mesoscopic particles.
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Epedigree in the Pharmaceutical Supply Chain
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Patricia Van Arnum
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EPedigree, track-and-trace technologies, and other tools for optimizing supply-chain management are of increasing importance to the pharmaceutical industry. The author examines the current regulatory and legislative framework for ePedigree for finished drug products as well as proposals to require electronic statements for pharmaceutical ingredients.
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Expansion Activity of CMOs
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Patricia Van Arnum
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The outlook is fairly optimistic as contract manufacturing organizations (CMOs) gather at CPhI Worldwide in Frankfurt. CMOs are expanding capacity for small-molecules, biologics, and finished-product manufacturing.
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