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Formulation Effects on the Thermomechanical Properties and Permeability of Free Films and Coating Films: Characterization of Cellulose Acetate Films
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| By
Jinghua Yuan
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Doug Dunn
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Nancy M. Clipse
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Ray J. Newton, Jr.
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The authors investigate the effects of a polyethylene glycol plasticizer and water on cellulose acetate film properties.
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Ruggedness of Visible Residue Limits for Cleaning Validation
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Richard J. Forsyth
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The author tests the ruggedness of VRL viewing conditions and defines optimal viewing conditions.
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Ultra High Performance Liquid Chromatography in the Contract Manufacturing Environment
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Allison A. Aldridge
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Roger Halbert
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Peter Groenewoud
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Ultra high performance liquid chromatography is advantageous in a contract laboratory because it is faster, more sensitive, and relies on smaller volumes of organic solvents than HPLC.
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Extending Calibrations for Near Infrared Assay of Tablets Using Synthetic Modeling and Variance from Placebos
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Robert Mattes
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Denise Root
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The authors extend the range of a near-infrared calibration model for tablet assay using production 'seed' spectra and synthetic spectra generated from placebos and 'pure' active pharmaceutical ingredient spectra.
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Modeling Pharmaceutical Powder-Flow Performance Using Particle-Size Distribution Data
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Matthew P. Mullarney
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Norma Leyva
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The authors present a simple and material-sparing approach for estimating the powder-flow performance of previously uncharacterized single-component bulk powders when only particle-size distribution data are available.
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New Leadership and More Resources Aim to Modernize FDA Operations
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Jill Wechsler
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Instead of protecting the public from unsafe drugs and contaminated foods, the Food and Drug Administration is a "hazard to public health," stated President Barack Obama in announcing his choices to head the agency and new efforts to improve food safety. Margaret Hamburg will be FDA's new commissioner, and Joshua Sharfstein principal deputy commissioner for drugs and medical products.
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Inside USP: Heparin Monographs Further Revised
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| By
Anita Y. Szajek
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Tina S. Morris
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William F. Koch
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Darrell R. Abernethy
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Roger L. Williams
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USP's Stage 2 heparin monograph revisions address identification, potency, and impurities.
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Detective Work
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Control, a senior compliance officer
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The source of a problem reveals itself after some investigation, or it may crash down on you.
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End-to-End Innovations
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Hallie Forcinio
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Integrated lines, flexible machines, and high-barrier materials enhance packaging options.
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API Outsourcing is Mixed
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Patricia Van Arnum
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Contract manufacturers of APIs and intermediates report gains, but express caution.
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Report From: India
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A. Nair
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With the economy down and multinational firms capitalizing on patents in developing countries, India's R&D sector still has a long way to grow.
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Coming Down the Pike: Treating Epilepsy
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Michelle Hoffman
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Scientists studying epilepsy have traditionally focused on the comings and goings of ions through molecular channels in nerve cells, and many current antiseizure therapies seek to modulate that dynamic.
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In the Spotlight
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Editors' Picks of Pharmaceutical Science & Technology Innovations
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