Pharmaceutical Technology, Apr 1, 2009 - Pharmaceutical Technology

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Pharmaceutical Technology, Apr 1, 2009
Articles
Influence of Superdisintegrants on the Rate of Drug Dissolution from Oral Solid Dosage Forms
By Jagdish Balasubramaniam , Tim Bee
The authors examine common superdisintegrants (i.e., crospovidone Type A, crospovidone Type B, croscarmellose sodium, and sodium starch glycolate) with a set of poorly soluble drug actives and evaluate in vitro drug dissolution.
Roller Compaction of Anhydrous Lactose and Blends of Anydrous Lactose with MCC
By Sander van Gessel , Henk van Duinen , Ivan Bogaerts
The authors studied the behavior of anhydrous lactose and the combination of anhydrous lactose and the combination of anhydrous lactose with microcrystalline cellulose on a pilot-scale roller compactor.
Using Polymers to Enhance Solubility of Poorly Soluble Drugs
By Kathrin Nollenberger , Andreas Gryczke , Takayuki Morita , Tatsuya Ishii
The authors demonstrate how melt-extrusion and spray-drying methods can help to prepare solid dispersions of poorly soluble drugs using Eudragit polymers.
A New Hypromellose Excipient for Direct Compression and Controlled Release
By Mark J. Hall , Brian D. Koblinski , Harold W. Bernthal , Karl V. Jacob , Kacee B. Ender
The authors examine the use of a hypromellose-based product as an excipient in a controlled release formulation using direct-compression tableting.
A Novel Pregelatinized Starch as a Sustained-Release Matrix Excipient
By Masaaki Endo , Kazuhiro Obae , Yoshihito Yaginuma
The authors examine the use of a novel highly functional pregelatinized starch as a controlled-release matrix excipient.

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Jim Miller Outsourcing Outlook Jim Miller Health Systems Raise the Bar on Reimbursing New Drugs
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerThe Mainstreaming of Continuous Flow API Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler Industry Seeks Clearer Standards for Track and Trace
Siegfried Schmitt Ask the Expert Siegfried SchmittData Integrity
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