Pharmaceutical Technology, Apr 1, 2009 - Pharmaceutical Technology

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Pharmaceutical Technology, Apr 1, 2009
Articles
Influence of Superdisintegrants on the Rate of Drug Dissolution from Oral Solid Dosage Forms
By Jagdish Balasubramaniam , Tim Bee
The authors examine common superdisintegrants (i.e., crospovidone Type A, crospovidone Type B, croscarmellose sodium, and sodium starch glycolate) with a set of poorly soluble drug actives and evaluate in vitro drug dissolution.
Roller Compaction of Anhydrous Lactose and Blends of Anydrous Lactose with MCC
By Sander van Gessel , Henk van Duinen , Ivan Bogaerts
The authors studied the behavior of anhydrous lactose and the combination of anhydrous lactose and the combination of anhydrous lactose with microcrystalline cellulose on a pilot-scale roller compactor.
Using Polymers to Enhance Solubility of Poorly Soluble Drugs
By Kathrin Nollenberger , Andreas Gryczke , Takayuki Morita , Tatsuya Ishii
The authors demonstrate how melt-extrusion and spray-drying methods can help to prepare solid dispersions of poorly soluble drugs using Eudragit polymers.
A New Hypromellose Excipient for Direct Compression and Controlled Release
By Mark J. Hall , Brian D. Koblinski , Harold W. Bernthal , Karl V. Jacob , Kacee B. Ender
The authors examine the use of a hypromellose-based product as an excipient in a controlled release formulation using direct-compression tableting.
A Novel Pregelatinized Starch as a Sustained-Release Matrix Excipient
By Masaaki Endo , Kazuhiro Obae , Yoshihito Yaginuma
The authors examine the use of a novel highly functional pregelatinized starch as a controlled-release matrix excipient.

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