Pharmaceutical Technology, Sep 1, 2010 - Pharmaceutical Technology

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PharmTech Europe

Pharmaceutical Technology, Sep 1, 2010
Articles
Asymmetric Routes to Chiral Secondary Alcohols
By Christopher J. Cobley , Karen E. Holt-Tiffin
The authors describe several examples of using asymmetric hydrogenation and biocatalysis for synthesizing several secondary alcohol compounds.
Method Development for Analysis and Isolation of Chiral Compounds Using Immobilized Stationary-Phase Technology
By Geoffrey B. Cox , David Ellis
The authors discuss the capabilities of immobilization technologies and the ability to use an expanded range of solvents for mobile-phase components and solvent dissolutions. This article is part of a special issue on APIs.
Strategies for Early-Stage Drug Development
By Patricia Van Arnum
Bristol-Myers Squibb's fit-for-purpose mode for clinical-trial materials for early-stage development seeks to achieve a better way in resource allocation. This article is part of a special issue on API Development, Formulation, Synthesis and Manufacturing.
Contract Manufacturing and Continuous Flow Reactor Technology for Early-Stage Drug Development
By James Hamby
The current trend in the pharmaceutical industry for the manufacture of small-molecule therapeutic agents is moving toward continuous flow processes. This article is part of a special issue on APIs.
Evolution of Continuous Chromatography: Moving Beyond Chiral Separations
By Olivier Dapremont
The author presents recent developments in simulated moving-bed chromatography in production of active pharmaceutical ingredients and intermediates. This article is part of a special issue on APIs.
Excipient Pedigree Verification
By Irwin Silverstein, PhD
The author explains the background behind the excipient pedigree and how to implement its use.
Microstructured Reactors for Rapid Process Development and Scale-Up
By Norbert Kockmann , Michael Gottsponer , Markus Eyholzer , Dominique M. Roberge
The authors discuss a continuous-flow reactor that avoids parallel channels and enables economic plant setup. This article is part of a special issue on API Development, Formulation, Synthesis and Manufacturing.
Using Polymer Technology to Enhance Bioavailability
By Timothy Bee , Mohammed Rahman
The authors review seven polymer classes that can be used to prepare solid-dispersion formulations.

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Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
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