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It's Goodbye From Me
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| By
Fedra Pavlou
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Rich Whitworth
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This issue will mark the last issue for me as Editor of PTE. It's time for me to move on to pastures new and to say my goodbyes.
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Direct Compression Versus Granulation
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Liesbeth Meeus
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Compressed tablets are the most widely used solid dosage form so they must satisfy a number of physical requirements in terms of hardness, disintegration ability, friability and uniformity.
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Moisture-Activated Dry Granulation
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Ismat Ullah
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Moisture Activated Dry Granulation (MADG) was developed in response to the difficulties experienced with wet granulation, in terms of endpoint, drying and milling. Wet granulation process endpoint is very sensitive to granulation time and shear. The wet granules need to be dried to a narrow range of moisture contents, which is difficult. The dried granules need to be milled, but the milled granules often have either too many fines or too many coarse particles (or both) — an undesirable bimodal distribution.
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One-Pot Processing And The Benefits For Granulation
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Griet Van Vaerenbergh
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One-pot processing is a term that includes any technology that combines different unit operations of a pharmaceutical production process into one machine.
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Pros And Cons Of Roll Compaction
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Imjak Jeon
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There are two types of widely used dry granulation methods: slugging and roll compaction. Currently, roll compaction is preferred to slugging because it offers greater capacity and ease of process control.
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Establishing Endpoints
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Tim Freeman
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The unit selected for wet granulation, whether it be a high shear mixer or a fluidised bed, has a marked impact on granule properties.
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Using Particle Size Analysis To Track The Granulation Process
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Alon Vaisman
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Use of in-process particle size analysis has enabled pharmaceutical scientists and process engineers to track the progress of a granulation process and detect its endpoint.
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Drug Scandal Shocks France
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Nathan Jessop
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In France, public confidence in health authorities and pharmaceutical industry has been shaken by a safety scandal over the drug Mediator (benfluorex hydrochloride).
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News
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With the future of healthcare revolving more and more around patient empowerment, data and healthy outcomes, the big question is can the traditionally slow and reserved pharma industry keep up with the new era?
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