Equipment and Processing Report, May 16, 2012 - Pharmaceutical Technology

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Equipment and Processing Report, May 16, 2012
Production Lines
Ongoing Challenges in Continuous Manufacturing
By Jennifer Markarian
Advances in process analytical technology and in defining lots for release are key for enabling use of continuous processes in solid-dosage manufacturing.
In the Mixer
Classifying Rouge Aids in Determining Maintenance and Remediation Procedures
By John Anderson
Properly identifying and classifying rouge, a form of surface corrosion that comes in many forms, is important in determining whether it may be affecting product quality and whether further actions are necessary.
Troubleshooting
Reducing Wet-Cake Drying Time
We are using a vacuum oven to dry our wet-cake intermediate. At 120 °C, it takes 26 hours on average to dry the material from 80% to 10% moisture. Can we shorten our drying time, possibly by agitating the product to improve heat transfer?
Editor's Picks
May 2012 Editor's Picks: Products from Koslow Scientific Company and Vaisala
PharmTech's monthly newsletter, Equipment and Processing Report, reviews the Editor's Picks for the May 2012 edition from Koslow Scientific Company and Vaisala.

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