Scale Up/Tech Transfer

Nov 01, 2010
Pharmaceutical Technology Europe
By Pharmaceutical Technology Editors
This article examines the difficulties in designing lyophilisation processes that can be faithfully scaled up to production volumes and suggests the most effective ways in which this can be achieved.
Sep 02, 2010
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors present three approaches that a contract development and manufacturing organization can consider when designing development and process-optimization studies that will provide useful data for scaling up a project.
Sep 01, 2010
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors discuss a continuous-flow reactor that avoids parallel channels and enables economic plant setup. This article is part of a special issue on API Development, Formulation, Synthesis and Manufacturing.
Apr 16, 2008
Equipment and Processing Report
By Pharmaceutical Technology Editors
A manufacturing line can be improved if technology transfer is implemented thoughtfully. Effective technology transfer helps to provide process efficiency and control and maintain product quality.
Oct 02, 2006
Pharmaceutical Technology
Whether you advance your technology from concept to commercialization or use a third party for parts or all of this work, the ability to do technology transfer flawlessly is essential to successful, efficient pharmaceutical production.
Sep 21, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Specialty Pharmaceutical Company Bentley Pharmaceuticals has entered into an agreement with Cardinal Health for the scale-up of clinical supplies for Bentley's intranasal insulin product candidate.
Sep 12, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Arlington, VA (Sept. 12)—At the American Association of Pharmaceutical Scientists meeting here, &quote;Real World Applications of PAT and QbD in Drug Process Development and Approval" (Sept. 11-12), chemical engineer and process modeler Michael L. Thompson, PhD, described how Procter & Gamble (West Chester, OH, www.pg.com) applies these mathematical tools to increase product quality and reduce development and trouble-shooting time for consumer and pharmaceutical products.
Oct 02, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Although agitation improves drying efficiency and ensures uniformity of the final dry material, it can also affect the physical properties of the product as it dries. This study evaluates the effect of scale up and equipment selection on an active ingredient undergoing granulation during the drying process.
Mar 01, 2005
Pharmaceutical Technology
In the manufacture of many pharmaceutical products, dry-particle blending is a critical step that directly affects content uniformity.
Mar 01, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The author points out some major obstacles to effective scale-up and describes methods available to pharmaceutical scientists for addressing scalability issues.
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