Scale Up

Sep 01, 2010
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors discuss a continuous-flow reactor that avoids parallel channels and enables economic plant setup. This article is part of a special issue on API Development, Formulation, Synthesis and Manufacturing.
Apr 19, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
If you’ve worked in the drug industry for a while, chances are good that you remember Pfizer’s Rezulin, which was produced through hot melt extrusion (HME). If you work for a major pharmaceutical manufacturer, it’s likely that your company owns a twin-screw extruder. Yet HME has not been a common way of manufacturing drugs, and many industry employees don’t understand the principles of HME or the advantages that the technique offers.
Mar 17, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
Continuous manufacturing could bring the pharmaceutical industry advantages such as improved product quality, easy scale-up, flexibility, and short cycle times. But how can a company switch from batch to continuous manufacturing?
Jan 20, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
Could flexible manufacturing change the standards for biopharmaceutical production? To find out, Equipment and Processing Report talked to James Robinson, vice-president of technical and quality operations at biotechnology company Novavax (Rockville, MD).
Jan 14, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
The authors sought to improve the productivity of protein synthesis by using a highly active cell-free extract from Escherichia coli and by optimizing buffer conditions and shaking conditions.
Nov 18, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
Recent advances in microreactor technology are improving the application and scale at which the technology can be applied.
Oct 21, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
The manufacturing process, which influences a drug's safety and efficacy, is particularly critical for drugs administered through injection, and personnel must closely supervise lyophilization to ensure product quality.
Aug 19, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
The US Food and Drug Administration?s Draft Guidance for Industry?Process Validation: General Principles and Practices provides a life-cycle approach for validating pharmaceutical processes and aims to help pharmaceutical companies achieve consistently high product quality.
Apr 16, 2008
Equipment and Processing Report
By Pharmaceutical Technology Editors
A manufacturing line can be improved if technology transfer is implemented thoughtfully. Effective technology transfer helps to provide process efficiency and control and maintain product quality.
Oct 02, 2006
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Whether you advance your technology from concept to commercialization or use a third party for parts or all of this work, the ability to do technology transfer flawlessly is essential to successful, efficient pharmaceutical production.
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