Scale Up

Mar 17, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
Continuous manufacturing could bring the pharmaceutical industry advantages such as improved product quality, easy scale-up, flexibility, and short cycle times. But how can a company switch from batch to continuous manufacturing?
Jan 20, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
Could flexible manufacturing change the standards for biopharmaceutical production? To find out, Equipment and Processing Report talked to James Robinson, vice-president of technical and quality operations at biotechnology company Novavax (Rockville, MD).
Jan 14, 2010
Equipment and Processing Report
By Pharmaceutical Technology Editors
The authors sought to improve the productivity of protein synthesis by using a highly active cell-free extract from Escherichia coli and by optimizing buffer conditions and shaking conditions.
Nov 18, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
Recent advances in microreactor technology are improving the application and scale at which the technology can be applied.
Oct 21, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
The manufacturing process, which influences a drug's safety and efficacy, is particularly critical for drugs administered through injection, and personnel must closely supervise lyophilization to ensure product quality.
Aug 19, 2009
Equipment and Processing Report
By Pharmaceutical Technology Editors
The US Food and Drug Administration?s Draft Guidance for Industry?Process Validation: General Principles and Practices provides a life-cycle approach for validating pharmaceutical processes and aims to help pharmaceutical companies achieve consistently high product quality.
Apr 16, 2008
Equipment and Processing Report
By Pharmaceutical Technology Editors
A manufacturing line can be improved if technology transfer is implemented thoughtfully. Effective technology transfer helps to provide process efficiency and control and maintain product quality.
Oct 02, 2006
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Whether you advance your technology from concept to commercialization or use a third party for parts or all of this work, the ability to do technology transfer flawlessly is essential to successful, efficient pharmaceutical production.
Sep 21, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Specialty Pharmaceutical Company Bentley Pharmaceuticals has entered into an agreement with Cardinal Health for the scale-up of clinical supplies for Bentley's intranasal insulin product candidate.
Sep 12, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Arlington, VA (Sept. 12)—At the American Association of Pharmaceutical Scientists meeting here, &quote;Real World Applications of PAT and QbD in Drug Process Development and Approval" (Sept. 11-12), chemical engineer and process modeler Michael L. Thompson, PhD, described how Procter & Gamble (West Chester, OH, www.pg.com) applies these mathematical tools to increase product quality and reduce development and trouble-shooting time for consumer and pharmaceutical products.
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