Solid/Semi-Solid Dosage

Nov 01, 2002
Pharmaceutical Technology Europe
The aim of this work was to investigate the compactibility, compressibility and drug release behaviour of different fractions of a commercially available ethyl cellulose.
Nov 01, 2002
Pharmaceutical Technology Europe
Consideration of the key process variable will define the ease with which coating processes can be transferred from development to production. This study investigates those factors influencing atomization from two spray guns and examines how development-scale procedures on interchangeable drum coating equipment compare with those typically used in a production environment.
Oct 01, 2002
Pharmaceutical Technology Europe
High quality tablet compression tooling is expensive, albeit consumable. With the potential for tooling damage during tablet production, transportation and storage, an acceptable method of cleaning, repairing, validating and storing tooling is required by anyone who manufactures tablets - and the regulatory inspection authorities.
Oct 01, 2002
Pharmaceutical Technology Europe
Using melt extrusion to prepare glass solutions of poorly water-soluble drugs with hydrophilic excipients offers an exciting and advantageous alternative to existing formulation methods such as spray-drying and co-melting. Investigating potential methods to increase water solubility begins early in drug development. Techniques described in this paper show how only a small quantity of drug can be used to determine its suitability for melt extrusion, allowing the method to be considered at the same time as salt screening and particle size reduction work, and could speed up the formulation process.
Oct 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The author offers a primer for choosing the correct granulation process to improve yields, reduce tablet defects, and enhance productivity.
Sep 02, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Spreadability of a semisolid forrmulation is affected by factors such as formulation characteristics, rate and time of shear, temperature, site of application, and the presence of various additives.
Sep 02, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Decision-making tools such as expert systems and artificial neural networks can be integrated to facilitate the development of optimal formulations of hard gelatin capsules.
Jul 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Dynamic powder-sampling methods may be the best techniques for obtaining a representative sample for determining particle-size distribution.
Apr 02, 2002
Pharmaceutical Technology
Powdered self-emulsified dosage forms provide an attractive alternative to filled-capsule preparations, but the selection of a proper excipient is crucial.
Mar 01, 2002
Pharmaceutical Technology
The delivery agent-mediated transport of low moleular weight heparin across Caco-2 cells is accomplished without opening the junctions or adversely affecting the structural integrity of the cell monolayer.
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