Editors' Picks of Pharmaceutical Science & Technology Innovations
To ensure that a tableting process will be predictable, active ingredients and excipients in powder form must undergo granulation. This process results in granules, which comprise several particles each, and helps personnel produce tablets within the desired specifications. This month's products aid the granulation process in various ways. A particle-size analyzer from Malvern Instruments helps streamline particle measurement. Whitehouse Scientific's image analyzer provides powder characterization. Bosch's extrusion line helps to form tablets accurately.
Particle-size analyzer facilitates dry-powder measurementMalvern Instruments's Mastersizer 3000 particle-size analyzer is designed to extend dry measurements to a wide range of sample types. It provides a 10-KHz data-acquisition rate, and all parameters for dry-powder measurement (i.e., sample feed rate, dispersion pressure, and system cleaning) are controlled through the software by its SOP interface. Its real-time feedback capability helps streamline method development and routine measurement.
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Image analyzer features particle characterization
The ShapeSizer image analyzer from Whitehouse Scientific can characterize particles in the size range of 1–5000 µm. The analyzer integrates a charge-coupled device camera with its software system, which is designed to provide a cost-effective solution for a variety of industrial particulate applications where size and shape are important parameters.
Extrusion and calendering line forms tablets accurately
The line includes the Pharma Extruder WCF 0040PH, which continually processes the substrate with active ingredients through the melting, mixing, kneading, aerating, tempering, and forming stages. Also included is the Pharma Calender BPK 0050, which is designed to ensure accurate forming of tablets by using dual rollers with forming cavities.