Oral solid dosage forms of small-molecule drugs represent the majority of pharmaceutical manufacturers' final products. Tablets are made by blending and granulating powdered ingredients. Coating is sometimes required to protect the active ingredient or control its release. Although tableting is a well-established process, production equipment for this dosage form continues to be refined. The products from Vector, Charles Ross and Son, and Diosna Dierks and Söhne featured this month are designed to assist different aspects of the granulation process.
Fluid-bed system offers flexibility
The VFC-LAB Mini is rated for aqueous and solvent applications and produces 0.5–1.5-kg quantities that can be scaled up to pilot-level systems. The self-contained, mobile system features quick utility connections and is easily dismantled for cleaning and inspection.
Blenders break up agglomerates
The machines are charged and discharged through a manually operated butterfly valve located 24 in. from the floor. While the twin shell rotates, granulated materials are continuously split and recombined during the cycle. Each blender's motor, belts, and drive train are fully integrated with Ross's control system.
System integrates granulation equipment
The CGS unit provides high containment and can limit operator exposure to < 0.4μg/m3 over 8 h of processing. Manufacturers can thus produce Category 4 potent compounds with the unit.
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