Thermo Fisher Scientific Introduces Triple Quadrupole LC-MS

Jul 01, 2013
By PharmTech Editors

Thermo Fisher Scientific Inc. has introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform featuring the Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the Thermo Scientific Endura triple-stage quadrupole mass spectrometer.

The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimize ion creation and transmission from the source to the detector, resulting in extreme sensitivity, which greatly improves results in applications such as peptide quantitation, metabolomics and biopharmaceutical QA/QC compared to previous Thermo Fisher triple quads, the company reports. In company laboratories, AIM-enhanced systems have measured 70 attograms of verapamil in plasma on column with excellent precision, an unprecedented level of performance.

The TSQ Quantiva MS system has the ability to perform 500 SRM experiments per second, and positive/negative polarity switching in 20ms with no signal loss. A new Ion Beam Guide and Neutral Blocker helps keep components free of contamination and eases maintenance when it is required. The TSQ Quantiva MS has been shown using synthetic serum stress tests to operate approximately three times longer between maintenance intervals than the company’s previous best systems, without loss of signal.

The TSQ Endura triple quadrupole mass spectrometer shares much of the technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument. It was built for workhorse applications requiring trace level quantitation, such as pharmaceutical QA/QC.

The TSQ Quantiva MS system uses the same source housings as the company’s new Orbitrap Fusion Tribrid LC-MS system. Both are designed for plug-and-play exchange between each other. Gas and electrical connections are made automatically when sources are installed, and ESI, APCI, and nanospray housings and probes are automatically recognized by the system.

The new triple quads share common software with the new Orbitrap Fusion Tribrid system. Method parameters can automatically pass between systems to support discovery and verification studies employing both instruments.