Too Much by Half: Misapplication of the Half-Cycle Approach to Sterilization

Published on: 
Pharmaceutical Technology, Pharmaceutical Technology-11-15-2016, Volume 2016 eBook, Issue 3
Pages: s21–s26

The half-cycle method for validating sterilization can have adverse effects on materials if used for steam sterilization.

The half-cycle method for validating sterilization, although necessary in its original context of ethylene oxide sterilization, can have adverse effects on materials if used for steam sterilization.

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The author describes some of these potential results and reviews historical and current thinking on validation of sterilization processes.

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