Pharmaceutical Technology-03-02-2006

Pharmaceutical Technology

Custom Manufacturers Target Chiral Chemistry, Catalysis, and Biosciences

March 02, 2006

Articles

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Facing still-sluggish market conditions and a changing world order in fine chemicals, the large Western custom manufacturers are responding by building their toolboxes in specialized technologies in chiral chemistry, catalysis, and biosciences and by adjusting their manufacturing networks via streamlining or investment in Asia.

March 2006

March 02, 2006

In the Field

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Flu vaccines. Dow veterinary vaccine made in plants. $1.95 billion FDA budget focuses on high-profile programs. Non-injectable insulins win approval. FDA releases guides to dissolution testing, quality overall summary, and new drug-label formats.

What is Disinfectant Validation?

March 02, 2006

Articles

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Adding a cleaning step to the field-testing protocol, and combining it with the data generated to register sanitizing and disinfectant agents under FIFRA and the CEN TC 216 work program, produces a sanitation-and-disinfection validation methodology that is cost-effective, simple, and time-saving.

Nefopam Containing Transdermal-Matrix Patches Based on Pressure-Sensitive Adhesive Polymers

March 02, 2006

Articles

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Transdermal matrix-type patches of Nefopam hydrochloride with a combination of pressure-sensitive adhesives were developed. The polymeric composition provided a controlled and sustained release of the drug from the patches and demonstrated favorable physicochemical characteristics.

Grow-Through and Penetration of the 0.2/0.22 "Sterilizing" Membranes

March 02, 2006

Articles

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The authors encourage the investigation into whether the occurrence of grow-through and the diminution in the size of certain organisms when in contact with given liquids are the same phenomenon manifested under different circumstances.

Characterization, Qualification, and Validation of a Disposable Final Filling Process for Parenteral and Ophthalmic Drugs

March 02, 2006

Articles

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Because of the growing popularity of single-use materials, the identification, characterization, and qualification of new materials used for disposable processes have become increasingly important for both regulatory and production purposes. This article describes one approach to identifying and validating the materials used in a disposable filling process.

Manpower and the Machine

March 02, 2006

This Time Around

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The outcomes of complex chains of reactions are hard to predict. Hindsight being 20–20, I can tell you that implementing the prohibition of alcohol in the 1920s-which was intended to reduce corruption and social problems, but actually lead to a rise in organized crime-was a bad idea.