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Transferring Energy to Hot Melt Extrusions

Fri, Apr 5, 2024 11:00 AM EDT{LOCAL_TZ}
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Event Overview:

In this exclusive Drug Digest video interview, Chris Spivey, Editorial Director, Pharmaceutical Technology, talks with industry experts about various aspects of drug formulation, through the lens of hot melt extrusion (HME) technology. HME is typically co-located with downstream processing and solid dose form manufacturing. Regulatory bodies continue to encourage quality management maturity (QMM), quality by design (QbD), and process analytical technology (PAT), - essential tools in the HME processes, to enhance product and process understanding. As a continuous process, HME is aptly suited to this framework. PAT tools including Raman and near-infrared (NIR) spectroscopy play an important role in real-time quality evaluation, and understanding of the extrusion process, in the production pharmaceutical dosage forms. Solid dispersion intermediate (SDI) appears to be the result of gel formation and osmogens. Counteracting SDI involves some tradeoffs including pore formation and (potentially) the types of pores formed. We will ask what role HME might play in leverahging this aspect of solid dose form manufacturing.  

This episode of Drug Digest is sponsored by:
  • Veltek
  • Adare
  • Aprecia
  • Thermofisher

Key Learning Objectives:
  • How HME enhances solubility/bioavailability for poorly soluble drugs
  • Why continuous processing allows for good process control & scalability
  • Role of solvents, solvent behavior and amorphous solid dispersions
  • HME  potential incorporation in controlled release delivery formulations
  • Ability to incorporate taste masking
Who Should Attend:
  • Medicinal chemists
  • CDMOs
  • Formulation scientists
  • Manufacturers
  • Excipient and API manufacturers
  • Purchasers and supply chain
  • QA/QC personnel
  • R&D personnel
  • Development scientists





For any technical questions please contact Jorge de la Bandera: JdelaBandera@mjhlifesciences.com 

Featured Speaker
Krizia M. Karry
Krizia M. Karry
Head of Global Technical Marketing
Pharma Solutions at BASF

Dr. Krizia M. Karry, Global Head of Technical Marketing for BASF Pharma Solutions, boasts over 15 years of expertise in the pharmaceutical industry. Renowned for her work in continuous manufacturing of solid oral drug products, she has advanced formulation design and optimization, hot melt extrusion processes, and the implementation of Process Analytical Technology (PAT) tools. Her influence extends across leading companies such as Pfizer, Bristol-Myers Squibb, AstraZeneca, and Eli Lilly, where she contributed to new product development. Krizia's insights have made her a sought-after speaker at scientific conferences globally, covering pharmaceutical formulations, continuous processes, hot melt extrusion, and the use of artificial intelligence (AI) in digital formulation design. With numerous published articles and co-authored book chapters, she drives innovation in pharmaceutical technology, focusing on formulations and process engineering for continuous manufacturing, shaping the future of drug delivery and formulation sciences with dedication and excellence.