Analytical Tools

Feb 01, 2007
Pharmaceutical Technology Europe
Raman spectroscopy has become a commonly used technique for physicochemical analysis that possesses many advantages over other analytical techniques. It is a very attractive characterization tool, not least because it enables measurements in water. However, very few examples of its application in an aqueous environment exist in literature. This paper provides some recent applications of Raman spectroscopy in pharmaceutical material and process characterization when water is present.
Feb 01, 2006
Pharmaceutical Technology
By Pharmaceutical Technology Editors
This article discusses the advantages and disadvantages of using solid-state NMR spectroscopy for the analysis of pharmaceutical solids.
Dec 01, 2005
Pharmaceutical Technology Europe
This article looks at the use of bracketing and matrixing to lower the number of stability samples required and, consequently, reduce the cost of sample production, testing and management. There is a common misconception that regulatory authorities will not accept such methods, but there is actually an International Conference on Harmonization guideline (ICH Q1D) on the subject. In fact, many of these designs have already been accepted and FDA members were among the first to describe matrixing.
Aug 01, 2005
Pharmaceutical Technology Europe
The first part of this article introduced the basic features of Raman spectroscopy and presented some examples of its application in the pharmaceutical industry. This second part focusses on the technique's application as a PAT tool within the pharmaceutical manufacturing environment. FDA's PAT initiative has provided motivation to explore the application of 'new' analytical technologies to the pharmaceutical manufacturing process and Raman spectroscopy shows great promise. The strengths and weaknesses of the technique as a potential PAT tool are discussed together with some examples of how this works in practice in a pharmaceutical manufacturing environment.
Jun 01, 2005
Pharmaceutical Technology Europe
Detection and identification of different polymorphic forms is, therefore, important throughout the drug development and manufacturing process.
Feb 02, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Analytical instrument suppliers are developing manufacturing-tailored tools that are small, precise, and easy to use.
Jan 01, 2005
Pharmaceutical Technology Europe
Laser diffraction is an important technique for particle size analysis. This article highlights the many advantages this tool has to offer.
Aug 01, 2004
Pharmaceutical Technology Europe
Tosoh has developed a new product — Toyopearl Toyoscreen that allows fast identification of the optimal resin for your sample. You can develop the optimal conditions for the separation in addition to the determination of the dynamic binding capacity. All the resins prepacked in these columns are real process resins concerning particle size. Results on the small columns can be scaled up to production.
Aug 01, 2004
Pharmaceutical Technology Europe
Rapid structural elucidation of compounds in complex mixtures is a powerful technique in metabolite, degradation and process control applications. The ability to follow the fragmentation pathway through sequential MSn transitions provides added confirmation and increases the selectivity for monitoring compounds of interest in a complex mixture. Previously, the limiting factors in applying this technique were sensitivity at MS4 and higher transitions, and the cycle time required to acquire multiple MSn spectra across a narrow LC peak. Recent developments in trapping, detection efficiencies and scan rates have reduced these limitations and enabled rapid characterization of multiple compounds from single chromatographic runs.
Jun 01, 2002
Pharmaceutical Technology
Measurements of lyophilization pressure are accurate only if the gauges that are used have been properly calibrated.
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