Analytics

Aug 01, 2004
Pharmaceutical Technology Europe
Rapid structural elucidation of compounds in complex mixtures is a powerful technique in metabolite, degradation and process control applications. The ability to follow the fragmentation pathway through sequential MSn transitions provides added confirmation and increases the selectivity for monitoring compounds of interest in a complex mixture. Previously, the limiting factors in applying this technique were sensitivity at MS4 and higher transitions, and the cycle time required to acquire multiple MSn spectra across a narrow LC peak. Recent developments in trapping, detection efficiencies and scan rates have reduced these limitations and enabled rapid characterization of multiple compounds from single chromatographic runs.
Jul 02, 2004
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors outline stability studies designed to evaluate the effect of temperature excursions on product quality that may occur during distribution.
Jun 02, 2004
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Pharmaceutical Science & Technology News
Jun 02, 2004
Pharmaceutical Technology
The role of microbial testing to ensure the sterility of aseptically filled sterile products is explained, from the product development phase to in-process monitoring to finished product testing.
Jun 01, 2004
Pharmaceutical Technology Europe
This article introduces the application of high-resolution ultrasonic spectroscopy (HR-US) for the analysis of emulsions and suspensions. The authors outline the principles of the technique and illustrate its application for analysis of the crystallization of lysozyme and the formation of a microemulsion.
May 02, 2004
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The author describes a separation method for two active ingredients in the contraceptive pill with liquid chromatography UV detection.
May 01, 2004
Pharmaceutical Technology
Current microbiological methods cannot measure microbial contamination at the levels that engineers and regulators seek to establish for aseptic processing cleanrooms. New approaches for assessing data and establishing alert and action levels are advocated, and an example of one analytical tool is considered.
Apr 01, 2004
Pharmaceutical Technology Europe
The bioavailability of some insoluble drugs is enhanced when they are dissolved in the solubilizing agent macrogol 400, although conventional hard capsules cannot tolerate the agent. This article investigates a PVA copolymer, which has been developed by the authors, examining its properties and its suitability as a material in capsule formulations.
Apr 01, 2004
Pharmaceutical Technology Europe
Dry powder inhalers are a well-accepted dosage form for pulmonary drug delivery and a wide variety are either currently available or in development. This article examines a premetered, capsule-based multidose inhaler for which different qualities of a-lactose monohydrate were screened.
Feb 01, 2004
Pharmaceutical Technology Europe
Cationic liposomes are widely used in gene therapy as a safe alternative to highly immunogenic viral vectors. Attachment of a tissue-specific ligand to the surface of the liposomes can increase specificity and reduce undesired transfection. Targeted liposomes can be categorized as either immunoliposomes or ligand-targeted liposomes. The author provides a brief review of tumour-specific and liver-targeted cationic liposomes and strategies for the development of liposome?ligand complexes.
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