What do mapping and imaging techniques add to traditional spectroscopic analysis for pharmaceutical applications?
Knowledge of the spatial location of different chemical components is valuable for a wide variety of applications, but is particularly useful for the analysis of tablets because it enables manufacturers to understand the links between raw materials, process parameters and a drug's critical quality attributes — the parameters that dictate clinical performance. By identifying the physical distribution of chemical components within the tablet, mapping and imaging techniques allow an appreciation of the relationship between structure and functionality. This helps with the more precise and sensitive definition of critical quality attributes and with the development of understanding of how these can be effectively controlled during manufacture. In this way, these systems closely support the knowledge-led approach enshrined in Quality by Design because they provide the insight necessary to gain a more complete model of product behaviour.Which applications require the extra spatial detail provided by imaging technology?
Assessing the information required for a particular application is crucial when selecting a spectroscopic system and the need (or not) for spatial detail is key. While case by case consideration is advised, the following examples review some common objectives and information goals.
Quality assurance and quality control
Troubleshooting/root cause analysis
For troubleshooting purposes, bulk measurements provide adequate information about chemical content (dosage) variation over time in a manufacturing run or between batches, or to study differences in properties such as averaged coating thickness between tablets. Spatial distribution information, on the other hand, can help to locate problems with coating integrity and thickness variation across a tablet's surface or at the apex of angled tablets, for example, which may lead to dissolution test failures.
For more in-depth investigation, such as root cause analysis of dosage variation and the underlying reasons for a failed batch, or batch-to-batch variability, spatially resolved measurements provide much more information and have become routine in many companies. This application demands careful consideration of every piece of available information and is consequently an area where imaging techniques have proven their value. Near-infrared chemical imaging, in particular, is favoured for troubleshooting because the field of view of a single image can encompass a whole tablet surface, or even multiple tablets, which makes it very fast and appropriate for the analysis of hundreds of tablets per day. This higher throughput is facilitated by automation and is essential to obtain enough information to confidently make decisions about processes.