The LCMS-8050 triple quadrupole mass spectrometer can perform both positive and negative ion analysis in a single run for faster throughput. The LCMS-8050 achieves high sensitivity through a patented ion optics system, a designed heated ESI probe, and UFsweeper III Collision Cell. The LCMS-8050 offers multiple reaction monitoring (MRM) speeds of 555 ch/sec and maintains spectrum quality, sensitivity, and accuracy at scan speeds up to 30,000 μ/sec. The Synchronized Survey Scan function allows users to obtain MRM data while simultaneously performing qualitative MS/MS scans. The LCMS-8050 provides 5-millisecond polarity switching and maintains ion intensity during polarity switching at high speeds. The ion source features a cable-free, tubeless housing when switching from ESI to APCI or dual-ionization mode.