Multilayer Tablets: A Piece Of Cake?

Multilayer tablets: A piece of cake or just a passing fad? We bring experts together to find out.
Jan 01, 2012
Volume 24, Issue 1

Q: How has demand for multilayer tablets altered in recent years? What factors have influenced this trend?

Marcus Behrens
Behrens: Fixed dose combination drugs are becoming increasingly popular, particularly as lifecycle management strategies seek to extend intellectual property and minimise generic exposure by creating an innovative dosage form. The multilayer tablet is a viable way to combine different actives for a synergic therapeutic effect, or different formulations of the same active in order to achieve a specific release profile. Furthermore, multilayer tablets can avoid interactions between different drugs and optimise each formulation in terms of pharmacokinetics and manufacturability.

Calvin: The growth of high-potency and combination drug products over the last decade has made multilayer and tablet in tablet (core tablet) hot topics in the pharma industry. These novel delivery systems have been essential not only in formulating new products, but also in helping pharmaceutical companies to extend patents.

CSA Plastock/Getty Images
Ethirajan: Among other advantages, triple-combination therapy in a single-dosage form is being used to promote better treatment adherence by providing a convenient single tablet. As well as increasing patient compliance, multilayer tablets can help to reduce the cost of medication.

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