The recommended dissolution method in relevant pharmacopoeias results in an overall dissolution profile, where the absorbance is the sum of all soluble compounds present in a formulation. However, efforts are being made to obtain 'individual' profiles — i.e., profiles of all component parts of a formulation — with some strategies having already been developed.6–11 Individual profiles enhance the information that we have for a formulation and, as such, it is just as important to obtain an individual profile as it is to obtain a global profile, in vitro bioavailability or manufacturing controls.
Because of regulatory requirements, the pharmaceutical industry must perform a large number of dissolution profiles every day, which often requires many replicas of the same formulation. This article describes how automating the simultaneous recording of several replicas of the same formulation can facilitate dissolution testing. Additionally, we will examine the simultaneous recording replicas of global and individual dissolution profiles for active principles present in a pharmaceutical formulation.