Oral Low Molecular Weight Heparin Absorption From Solution and Solid Dosage Forms in Rat, Dog, and Monkey Models

Leone&#45Bay,Andrea;Gerspach,Linda;O’Shaughnessy,Catherina;Agarwal,Rajesh;Rosado-Gray,Connie;Rivera-Schaub,Theresa;Baughman,Robert;

Oral Low Molecular Weight Heparin Absorption From Solution and Solid Dosage Forms in Rat, Dog, and Monkey Models

Published on: March 1, 2002

Andrea Leone-Bay, Linda Gerspach, Catherina O’Shaughnessy, Rajesh Agarwal, Connie Rosado-Gray, Theresa Rivera-Schaub, Robert A. Baughman

Pharmaceutical Technology, Pharmaceutical Technology-03-02-2002, Volume 26, Issue 3

The delivery agent-mediated transport of low moleular weight heparin across Caco-2 cells is accomplished without opening the junctions or adversely affecting the structural integrity of the cell monolayer.